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Via Christi Health is one of the Midwest's leading sites for advanced clinical research, conducting clinical trials through Via Christi Research, National Cancer Institute trials through the Wichita Clinical Community Oncology Program and preclinical studies through its Orthopaedic Research Institute.

Via Christi Research, since 1988, has conducted hundreds of drug and device trials for dozens of global clients, providing Kansans access to otherwise unavailable medical options. Its 12-bed Clinical Research Unit is dedicated to inpatient and Phase I trials. In 2004 it became one of the nation's few clinical research institutes to achieve ISO 9001-2000 certification – a prestigious, internationally recognized standard of consistent quality.

The Wichita Clinical Community Oncology Program (CCOP) provides opportunities to enroll in investigational treatment, detection and prevention studies of the National Cancer Institute. Based at Via Christi Hospital St. Francis, CCOP collaborates with the Southwest Oncology Group, North Central Cancer Treatment Group (Mayo Clinic), MD Anderson Cancer Center, National Surgical Adjuvant Breast and Bowel Project, Children's Oncology Group and the University of Rochester Cancer Center. Wichita's CCOP has received national recognition for its effective methods of patient recruitment and physician support.

The Orthopaedic Research Institute conducts applied research and development for orthopaedics and other medical specialties, with a strong emphasis on the design, development and testing of orthopedic implants, surgical instruments, and related hardware/software systems.